GENEYE® Monkeypox Virus ERA Assay
Product code: GD010
Introduction
Monkeypox is a viral zoonosis of humans that had remained a neglected tropical disease in sub-Saharan Africa for over half a century until an initial cluster of infections involving dozens of United Kingdom residents was recognized and reported to local health authorities in May 2022, according to the World Health Organization. The emergence of this disease has been characterized by rapid international spread with a growing number of cases in new geographic areas, a preponderance of disease among members of a distinct social group, and a somewhat atypical clinical presentation, collectively being shaped in part by increased international travel, human behavior, and viral pathogenicity. In the regions of West and Central Africa where it is endemic, an increase in human case counts since the year 2005 has been fueled by climate change, deforestation, warfare, human migration, and decreased herd immunity from remote smallpox vaccination. In this review, we discuss the taxonomy and phylogeny of Monkeypox virus, its association with the smallpox vaccination campaign, its history of causing outbreaks of human disease in regions where it is endemic in wildlife, its association with outbreaks in areas where it is nonendemic, the clinical manifestations of disease, laboratory diagnostic methods, case management, public health interventions, and future directions.
This kit is designed with specific primers and probes targeting the conserved region of Monkeypox species, generating fluorescence signals on a constant temperature nucleic acid amplification instrument. By employing POCT detection, it realizes qualitative and genotypic identification of Monkeypox at the nucleic acid level.